Depressive symptoms evaluated by the Calgary Depression Scale for Schizophrenia (CDSS): Genetic vulnerability and sex effects

Migdyrai Martín-Reyes, Raúl Mendoza, Mayelín Domínguez, Antonio Caballero, Tania Marta Bravo, Thais Díaz, Seidel Gerra, Agustín Ibáñez, Andres Ruiz Linares

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

The present study compares the occurrence of depressive symptoms evaluated by the Calgary Depression Scale for Schizophrenia (CDSS) in patients of Multiplex (MS) and Simplex Schizophrenia families (SS). The Positive and Negative Syndrome Scale (PANSS) was used to evaluate psychopathology. A total of 206 paranoid schizophrenia patients were studied according DSM-IV criteria. The Family Interview for Genetic Studies (FIGS) was used to study the families. A result in the FIGS for a positive family history of schizophrenia was referred as MS (patients); its lack as SS (patients). CDSS scores were compared among MS and SS patients and possible sex differences intra- and inter-groups were explored. In the analysis of our sample (30) 19% of the total persons with schizophrenia group was depressed. The depressive symptoms measured by the CDSS were higher in females and the MS males group. Males from MS group showed more depressive symptoms than males from SS group. No differences with females from both groups were found. Findings in this study underscore the importance of gender and family history in understanding the heterogeneity of schizophrenia. This study suggests that sex and familiar history are important to consider in studying depressive symptoms.

Original languageEnglish
Pages (from-to)55-61
Number of pages7
JournalPsychiatry Research
Volume189
Issue number1
DOIs
StatePublished - 30 Aug 2011

Keywords

  • Depressive symptoms
  • Genetic
  • Schizophrenia
  • Sex

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