Abstract
Dementia with Lewy bodies (DLB) research has seen a significant growth in international collaboration over the last three decades. However, researchers face a challenge in identifying large and diverse samples capable of powering longitudinal studies and clinical trials. The DLB research community has begun to focus efforts on supporting the development and harmonization of consortia, while also continuing to forge networks within which data and findings can be shared. This article describes the current state of DLB research collaborations on each continent. We discuss several established DLB cohorts, many of whom have adopted a common framework, and identify emerg-ing collaborative initiatives that hold the potential to expand DLB networks and diver-sify research cohorts. Our findings identify geographical areas into which the global DLB networks should seek to expand, and we propose strategies, such as the cre-ation of data-sharing platforms and the harmonization of protocols, which may further potentiate international collaboration.
Original language | English |
---|---|
Article number | e12235 |
Journal | Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring |
Volume | 13 |
Issue number | 1 |
DOIs | |
State | Published - 2021 |
Keywords
- Collaboration
- Consortia
- Dementia with Lewy bodies
- Global strategy
- Lewy body dementia
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In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 13, No. 1, e12235, 2021.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Dementia with lewy bodies research consortia
T2 - A global perspective from the istaart lewy body dementias professional interest area working group
AU - the ISTAART Lewy body dementias Consortia Working Group
AU - D’antonio, Fabrizia
AU - Kane, Joseph P.M.
AU - Ibañez, Agustin
AU - Lewis, Simon J.G.
AU - Camicioli, Richard
AU - Wang, Huali
AU - Yu, Yueyi
AU - Zhang, Jing
AU - Ji, Yong
AU - Borda, Miguel Germán
AU - Kandadai, Rukmini Mridula
AU - Babiloni, Claudio
AU - Bonanni, Laura
AU - Ikeda, Manabu
AU - Boeve, Bradley F.
AU - Leverenz, James B.
AU - Aarsland, Dag
N1 - Funding Information: This manuscript was facilitated by the Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART), through the Lewy body dementias professional interest area (PIA). The views and opinions expressed by authors in this publication represent those of the authors and do not necessarily reflect those of the greater PIA membership, ISTAART, or the Alzheimer’s Association. The authors are particularly grateful for the support and diligence of Jodi Titiner and Chris Weber in supporting the LBD PIA and the production of this manuscript. Laura Bonanni, Bradley Boeve, Miguel Germán Borda, Fabrizia D’Antonio, Manabu Ikeda, Yong Ji, Rukmini Mridula Kandadai, Joseph Kane, Simon Lewis, Huali Wang, Yueyi Yu, and Jing Zhang have no funding sources to acknowledge. Dag Aars-land is a Royal Society Wolfson Research Merit Award Holder and would like to thank the Wolfson Foundation and the Royal Society for their support. Professor Aarsland is supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health. Claudio Babiloni is supported by the European H2020 Marie S. Curie ITN-ETN grant. Richard Camicioli has received research funding support from the Canadian Institutes for Health Research (CIHR), the Lewy body Dementia Team of the Canadian Consortium on Neurodegener-ation of Aging (CCNA), Brain Canada, and the Michael J. Fox Foundation. Agustin Ibañez is partially supported by grants from Alzheimer’s Association GBHI ALZ UK-20-639295, Takeda CW2680521, CON-ICET, ANID/FONDAP/15150012, ANID/Fondecyt 1210195, Sistema General de Regalías (BPIN2018000100059), Universidad del Valle (CI 5316), and the MULTI-PARTNER CONSORTIUM TO EXPAND DEMENTIA RESEARCH IN LATIN AMERICA (ReDLat, supported by National Institutes of Health, National Institutes of Aging [R01 AG057234], Alzheimer’s Association [SG-20-725707], Tau Consortium, and Global Brain Health Institute). The contents of this publication are solely the responsibility of the authors and do not represent the official views of these institutions. James Leverenz is supported by the National Institute of Health (UO1 NS100610 and P30 AG062428), the Douglas Herthel DVM Memorial Research Fund, and the Jane and Lee Seidman Fund. Funding Information: The DLB Society Japan (DLBSJ) was established by Dr. Kenji Kosaka in 2007 and has more than 400 members. It is funded by a grant from the Japan Foundation for Neuroscience and Mental Health. The DLBSJ’s primary purpose is to stimulate basic and clinical research on DLB and to increase public awareness in finding better management options. Core members and their multicenter networks have contributed significantly to the advancement of diagnostic techniques. In particular, DLBSJ have led research on the use of MIBG myocardial scintigraphy25 and standardized methods for its use in discriminating probable DLB and probable AD. Funding Information: National Health and Medical Research Council (NHMRC) Dementia Research Team Grant; NHMRC-ARC Dementia Fellowship; NHMRC Investigator Grant Funding Information: This manuscript was facilitated by the Alzheimer?s Association International Society to Advance Alzheimer?s Research and Treatment (ISTAART), through the Lewy body dementias professional interest area (PIA). The views and opinions expressed by authors in this publica-tion represent those of the authors and do not necessarily reflect those of the greater PIA membership, ISTAART, or the Alzheimer?s Associa-tion. The authors are particularly grateful for the support and diligence of Jodi Titiner and Chris Weber in supporting the LBD PIA and the production of this manuscript. Laura Bonanni, Bradley Boeve, Miguel Germ?n Borda, Fabrizia D?Antonio, Manabu Ikeda, Yong Ji, Rukmini Mridula Kandadai, Joseph Kane, Simon Lewis, Huali Wang, Yueyi Yu, and Jing Zhang have no funding sources to acknowledge. Dag Aars-land is a Royal Society Wolfson Research Merit Award Holder and would like to thank the Wolfson Foundation and the Royal Society for their support. Professor Aarsland is supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King?s College Lon-don. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health. Claudio Babiloni is supported by the European H2020 Marie S. Curie ITN-ETN grant. Richard Camicioli has received research funding support from the Canadian Institutes for Health Research (CIHR), the Lewy body Dementia Team of the Canadian Consortium on Neurodegener-ation of Aging (CCNA), Brain Canada, and the Michael J. Fox Founda-tion. Agustin Iba?ez is partially supported by grants from Alzheimer?s Association GBHI ALZ UK-20-639295, Takeda CW2680521, CON-ICET, ANID/FONDAP/15150012, ANID/Fondecyt 1210195, Sistema General de Regal?as (BPIN2018000100059), Universidad del Valle (CI 5316), and the MULTI-PARTNER CONSORTIUM TO EXPAND DEMENTIA RESEARCH IN LATIN AMERICA (ReDLat, supported by National Institutes of Health, National Institutes of Aging [R01 AG057234], Alzheimer?s Association [SG-20-725707], Tau Consor-tium, and Global Brain Health Institute). The contents of this publica-tion are solely the responsibility of the authors and do not represent the official views of these institutions. James Leverenz is supported by the National Institute of Health (UO1 NS100610 and P30 AG062428), the Douglas Herthel DVM Memorial Research Fund, and the Jane and Lee Seidman Fund. Funding Information: São Paulo Research Foundation (FAPESP) Publisher Copyright: © 2021 The Authors. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer’s Association.
PY - 2021
Y1 - 2021
N2 - Dementia with Lewy bodies (DLB) research has seen a significant growth in international collaboration over the last three decades. However, researchers face a challenge in identifying large and diverse samples capable of powering longitudinal studies and clinical trials. The DLB research community has begun to focus efforts on supporting the development and harmonization of consortia, while also continuing to forge networks within which data and findings can be shared. This article describes the current state of DLB research collaborations on each continent. We discuss several established DLB cohorts, many of whom have adopted a common framework, and identify emerg-ing collaborative initiatives that hold the potential to expand DLB networks and diver-sify research cohorts. Our findings identify geographical areas into which the global DLB networks should seek to expand, and we propose strategies, such as the cre-ation of data-sharing platforms and the harmonization of protocols, which may further potentiate international collaboration.
AB - Dementia with Lewy bodies (DLB) research has seen a significant growth in international collaboration over the last three decades. However, researchers face a challenge in identifying large and diverse samples capable of powering longitudinal studies and clinical trials. The DLB research community has begun to focus efforts on supporting the development and harmonization of consortia, while also continuing to forge networks within which data and findings can be shared. This article describes the current state of DLB research collaborations on each continent. We discuss several established DLB cohorts, many of whom have adopted a common framework, and identify emerg-ing collaborative initiatives that hold the potential to expand DLB networks and diver-sify research cohorts. Our findings identify geographical areas into which the global DLB networks should seek to expand, and we propose strategies, such as the cre-ation of data-sharing platforms and the harmonization of protocols, which may further potentiate international collaboration.
KW - Collaboration
KW - Consortia
KW - Dementia with Lewy bodies
KW - Global strategy
KW - Lewy body dementia
UR - http://www.scopus.com/inward/record.url?scp=85119688366&partnerID=8YFLogxK
U2 - 10.1002/dad2.12235
DO - 10.1002/dad2.12235
M3 - Article
AN - SCOPUS:85119688366
SN - 2352-8729
VL - 13
JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
IS - 1
M1 - e12235
ER -