Dementia in Latin America: Paving the way toward a regional action plan

Mario Alfredo Parra; Sandra Baez; Lucas Sedeño; Cecilia Gonzalez Campo; Hernando Santamaría-García; Ivan Aprahamian; Paulo H.F. Bertolucci; Julian Bustin; Maria Aparecida Camargos Bicalho; Carlos Cano-Gutierrez; Paulo Caramelli; Marcia L.F. Chaves; Patricia Cogram; Bárbara Costa Beber; Felipe A. Court; Leonardo Cruz de Souza; Nilton Custodio; Andres Damian; Myriam de la Cruz; Roberta Diehl Rodriguez; Sonia Maria Dozzi Brucki; Lais Fajersztajn; Gonzalo A. Farías; Fernanda G. De Felice; Raffaele Ferrari; Fabricio Ferreira de Oliveira; Sergio T. Ferreira; Ceres Ferretti; Marcio Luiz Figueredo Balthazar; Norberto Anizio Ferreira Frota; Patricio Fuentes; Adolfo M. García; Patricia J. Garcia; Fábio Henrique de Gobbi Porto; Lissette Duque Peñailillo; Henry Willy Engler; Irene Maier; Ignacio F. Mata; Christian Gonzalez-Billault; Oscar L. Lopez; Laura Morelli; Ricardo Nitrini; Yakeel T. Quiroz; Alejandra Guerrero Barragan; David Huepe; Fabricio Joao Pio; Claudia Kimie Suemoto; Renata Kochhann; Silvia Kochen; Fiona Kumfor; Serggio Lanata; Bruce Miller; Leticia Lessa Mansur; Mirna Lie Hosogi; Patricia Lillo; Jorge Llibre Guerra; David Lira; Francisco Lopera; Adelina Comas; José Alberto Avila-Funes; Ana Luisa Sosa; Claudia Ramos; Elisa de Paula França Resende; Heather M. Snyder; Ioannis Tarnanas; Jenifer Yokoyama; Juan Llibre; Juan Felipe Cardona; Kate Possin; Kenneth S. Kosik; Rosa Montesinos; Sebastian Moguilner; Patricia Cristina Lourdes Solis; Renata Eloah de Lucena Ferretti-Rebustini; Jeronimo Martin Ramirez; Diana Matallana; Lingani Mbakile-Mahlanza; Alyne Mendonça Marques Ton; Ronnielly Melo Tavares; Eliane C. Miotto; Graciela Muniz-Terrera; Luis Arnoldo Muñoz-Nevárez; David Orozco; Maira Okada de Oliveira; Olivier Piguet; Maritza Pintado Caipa; Stefanie Danielle Piña Escudero; Lucas Porcello Schilling; André Luiz Rodrigues Palmeira; Mônica Sanches Yassuda; Jose Manuel Santacruz-Escudero; Rodrigo Bernardo Serafim; Jerusa Smid; Andrea Slachevsky; Cecilia Serrano; Marcio Soto-Añari; Leonel Tadao Takada; Lea Tenenholz Grinberg; Antonio Lucio Teixeira; Maira Tonidandel Barbosa; Dominic Trépel; Agustin Ibanez

doi:10.1002/alz.12202

Dementia in Latin America: Paving the way toward a regional action plan

Mario Alfredo Parra, Sandra Baez, Lucas Sedeño, Cecilia Gonzalez Campo, Hernando Santamaría-García, Ivan Aprahamian, Paulo H.F. Bertolucci, Julian Bustin, Maria Aparecida Camargos Bicalho, Carlos Cano-Gutierrez, Paulo Caramelli, Marcia L.F. Chaves, Patricia Cogram, Bárbara Costa Beber, Felipe A. Court, Leonardo Cruz de Souza, Nilton Custodio, Andres Damian, Myriam de la Cruz, Roberta Diehl RodriguezSonia Maria Dozzi Brucki, Lais Fajersztajn, Gonzalo A. Farías, Fernanda G. De Felice, Raffaele Ferrari, Fabricio Ferreira de Oliveira, Sergio T. Ferreira, Ceres Ferretti, Marcio Luiz Figueredo Balthazar, Norberto Anizio Ferreira Frota, Patricio Fuentes, Adolfo M. García, Patricia J. Garcia, Fábio Henrique de Gobbi Porto, Lissette Duque Peñailillo, Henry Willy Engler, Irene Maier, Ignacio F. Mata, Christian Gonzalez-Billault, Oscar L. Lopez, Laura Morelli, Ricardo Nitrini, Yakeel T. Quiroz, Alejandra Guerrero Barragan, David Huepe, Fabricio Joao Pio, Claudia Kimie Suemoto, Renata Kochhann, Silvia Kochen, Fiona Kumfor, Serggio Lanata, Bruce Miller, Leticia Lessa Mansur, Mirna Lie Hosogi, Patricia Lillo, Jorge Llibre Guerra, David Lira, Francisco Lopera, Adelina Comas, José Alberto Avila-Funes, Ana Luisa Sosa, Claudia Ramos, Elisa de Paula França Resende, Heather M. Snyder, Ioannis Tarnanas, Jenifer Yokoyama, Juan Llibre, Juan Felipe Cardona, Kate Possin, Kenneth S. Kosik, Rosa Montesinos, Sebastian Moguilner, Patricia Cristina Lourdes Solis, Renata Eloah de Lucena Ferretti-Rebustini, Jeronimo Martin Ramirez, Diana Matallana, Lingani Mbakile-Mahlanza, Alyne Mendonça Marques Ton, Ronnielly Melo Tavares, Eliane C. Miotto, Graciela Muniz-Terrera, Luis Arnoldo Muñoz-Nevárez, David Orozco, Maira Okada de Oliveira, Olivier Piguet, Maritza Pintado Caipa, Stefanie Danielle Piña Escudero, Lucas Porcello Schilling, André Luiz Rodrigues Palmeira, Mônica Sanches Yassuda, Jose Manuel Santacruz-Escudero, Rodrigo Bernardo Serafim, Jerusa Smid, Andrea Slachevsky, Cecilia Serrano, Marcio Soto-Añari, Leonel Tadao Takada, Lea Tenenholz Grinberg, Antonio Lucio Teixeira, Maira Tonidandel Barbosa, Dominic Trépel, Agustin Ibanez

School of Psychology

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.

Original language	English
Pages (from-to)	295-313
Number of pages	19
Journal	Alzheimer's and Dementia
Volume	17
Issue number	2
DOIs	https://doi.org/10.1002/alz.12202
State	Published - Feb 2021

Keywords

Latin America
biomarkers
clinical trials
dementia
epidemiology
evidence-based recommendations
genetics
knowledge to action framework
networking and translational research
nonpharmacological interventions

Access to Document

10.1002/alz.12202

Cite this

Parra, M. A., Baez, S., Sedeño, L., Gonzalez Campo, C., Santamaría-García, H., Aprahamian, I., Bertolucci, P. H. F., Bustin, J., Camargos Bicalho, M. A., Cano-Gutierrez, C., Caramelli, P., Chaves, M. L. F., Cogram, P., Beber, B. C., Court, F. A., de Souza, L. C., Custodio, N., Damian, A., de la Cruz, M., ... Ibanez, A. (2021). Dementia in Latin America: Paving the way toward a regional action plan. Alzheimer's and Dementia, 17(2), 295-313. https://doi.org/10.1002/alz.12202

@article{f38fe78c7ff349708b5da67286167792,

title = "Dementia in Latin America: Paving the way toward a regional action plan",

abstract = "Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.",

keywords = "Latin America, biomarkers, clinical trials, dementia, epidemiology, evidence-based recommendations, genetics, knowledge to action framework, networking and translational research, nonpharmacological interventions",

author = "Parra, {Mario Alfredo} and Sandra Baez and Lucas Sede{\~n}o and {Gonzalez Campo}, Cecilia and Hernando Santamar{\'i}a-Garc{\'i}a and Ivan Aprahamian and Bertolucci, {Paulo H.F.} and Julian Bustin and {Camargos Bicalho}, {Maria Aparecida} and Carlos Cano-Gutierrez and Paulo Caramelli and Chaves, {Marcia L.F.} and Patricia Cogram and Beber, {B{\'a}rbara Costa} and Court, {Felipe A.} and {de Souza}, {Leonardo Cruz} and Nilton Custodio and Andres Damian and {de la Cruz}, Myriam and {Diehl Rodriguez}, Roberta and Brucki, {Sonia Maria Dozzi} and Lais Fajersztajn and Far{\'i}as, {Gonzalo A.} and {De Felice}, {Fernanda G.} and Raffaele Ferrari and {de Oliveira}, {Fabricio Ferreira} and Ferreira, {Sergio T.} and Ceres Ferretti and {Figueredo Balthazar}, {Marcio Luiz} and {Ferreira Frota}, {Norberto Anizio} and Patricio Fuentes and Garc{\'i}a, {Adolfo M.} and Garcia, {Patricia J.} and {de Gobbi Porto}, {F{\'a}bio Henrique} and {Duque Pe{\~n}ailillo}, Lissette and Engler, {Henry Willy} and Irene Maier and Mata, {Ignacio F.} and Christian Gonzalez-Billault and Lopez, {Oscar L.} and Laura Morelli and Ricardo Nitrini and Quiroz, {Yakeel T.} and {Guerrero Barragan}, Alejandra and David Huepe and Pio, {Fabricio Joao} and Suemoto, {Claudia Kimie} and Renata Kochhann and Silvia Kochen and Fiona Kumfor and Serggio Lanata and Bruce Miller and Mansur, {Leticia Lessa} and Hosogi, {Mirna Lie} and Patricia Lillo and {Llibre Guerra}, Jorge and David Lira and Francisco Lopera and Adelina Comas and Avila-Funes, {Jos{\'e} Alberto} and Sosa, {Ana Luisa} and Claudia Ramos and Resende, {Elisa de Paula Fran{\c c}a} and Snyder, {Heather M.} and Ioannis Tarnanas and Jenifer Yokoyama and Juan Llibre and Cardona, {Juan Felipe} and Kate Possin and Kosik, {Kenneth S.} and Rosa Montesinos and Sebastian Moguilner and Solis, {Patricia Cristina Lourdes} and Ferretti-Rebustini, {Renata Eloah de Lucena} and Ramirez, {Jeronimo Martin} and Diana Matallana and Lingani Mbakile-Mahlanza and {Marques Ton}, {Alyne Mendon{\c c}a} and Tavares, {Ronnielly Melo} and Miotto, {Eliane C.} and Graciela Muniz-Terrera and Mu{\~n}oz-Nev{\'a}rez, {Luis Arnoldo} and David Orozco and {Okada de Oliveira}, Maira and Olivier Piguet and {Pintado Caipa}, Maritza and {Pi{\~n}a Escudero}, {Stefanie Danielle} and Schilling, {Lucas Porcello} and {Rodrigues Palmeira}, {Andr{\'e} Luiz} and Yassuda, {M{\^o}nica Sanches} and Santacruz-Escudero, {Jose Manuel} and Serafim, {Rodrigo Bernardo} and Jerusa Smid and Andrea Slachevsky and Cecilia Serrano and Marcio Soto-A{\~n}ari and Takada, {Leonel Tadao} and Grinberg, {Lea Tenenholz} and Teixeira, {Antonio Lucio} and Barbosa, {Maira Tonidandel} and Dominic Tr{\'e}pel and Agustin Ibanez",

note = "Funding Information: The Expert Meeting was supported by Alzheimer's Society UK grants awarded to MP in collaboration with AI (AS‐R42303, AS‐SF‐14‐008). AS is supported by CONICYT / FONDAP /15150012; Conicyt/ Fondecyt Regular/ 1140423 and Basal Funds for Centers of Excellence, Project FB 0003 from the Associative Research Program of CONICYT. FL is supported by a grant API COLOMBIA funded by GENENTECH and Banner Institute. FK is supported by a National Health and Medical Research Council of Australia (NHMRC)‐Australian Research Council Dementia Research Development Fellowship (APP1097026). OP is supported by an NHMRC Senior Research Fellowship (APP1103258). FFDO is supported by FAPESP ‐ The State of S{\~a}o Paulo Research Foundation (grant #2015/10109‐5). The support from Alzheimer´s Scotland Dementia Research and the Centre for Cognitive Ageing and Cognitive Epidemiology part of the cross council Lifelong Health and Wellbeing Initiative (MR/K026992/1) both from the University of Edinburgh is also acknowledged. FS is supported by Geroscience Center for Brain Health and Metabolism (FONDAP‐15150012) and Fondo Nacional de Desarrollo Cient{\'i}fico y Tecnol{\'o}gico (FONDECYT, No. 1150766). RAV is supported by CONICYT AFB 170008 and by Faculty of Sciences, University of Chile, PAIFAC grant. PC is supported by CNPq, Brazil (bolsa de produtividade em pesquisa). PL is supported by FONDAP Program Grant 15150012 & by Conicyt/Fondecyt Regular/ 1160940. STF is supported by National Institute for Translational Neuroscience (Brazil, Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico (CNPq/Brazil) and Funda{\c c}{\~a}o de Amparo {\`a} Pesquisa do Estado do Rio de Janeiro (FAPERJ/Brazil). BCB is supported by Alzheimer's Association and Global Brain Health Institute (GBHI_ALZ‐18‐542347). LTG is supported by NIH K24AG053435. MLFC is supported by CNPq (bolsa de produtividade em pesquisa). RDR is supported by FAPESP (2016/24326‐0) and the Alzheimer´s Association (AARF‐18‐566005). LD is partially supported by Neuromedicenter. RF is supported by Alzheimer's Society (grant # 284). LCS is supported by Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico (CNPq/Brazil). MSY is supported by Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico (CNPq/Brazil) and S{\~a}o Paulo Research Foundation (FAPESP/BRAZIL). MACB is supported by Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico (CNPq/Brazil) and Minas Gerais Research Foundation (FAPEMIG/BRAZIL). IA receives National public grant level 2 from the National Council for Scientific and Technological Development (Ministry of Science, Technology, Innovation and Communications, Brazil). HMS is a full‐time employee of the Alzheimer's Association. AI is partially supported by grants from CONICET, FONCyT‐PICT 2017‐1818, FONCyT‐PICT 2017‐1820, FONDAP 15150012, the Interamerican Development Bank (IDB), Alzheimer's Association GBHI ALZ UK‐20‐639295, and the MULTI‐PARTNER CONSORTIUM TO EXPAND DEMENTIA RESEARCH IN LATIN AMERICA [ReDLat, supported by National Institutes of Health, National Institute on Aging (R01 AG057234), Alzheimer's Association (SG‐20‐725707), Tau Consortium, and Global Brain Health Institute)]. The contents of this publication are solely the responsibility of the authors and do not represent the official views of these Institutions. The other authors declare no conflict of interests. Funding Information: The authors thank Laura Bleiler from the Alzheimer's Association (AA) for proofreading the article. The authors also thank the Inter‐American Development Bank (IDB) and the the MULTI‐PARTNER CONSORTIUM TO EXPAND DEMENTIA RESEARCH IN LATIN AMERICA [ReDLat, supported by National Institutes of Health, National Institutes of Aging (R01 AG057234), Alzheimer's Association (SG‐20‐725707), Tau Consortium, and Global Brain Health Institute] and the grant Alzheimer's Association GBHI ALZ UK‐20‐639295. The contents of this publication are solely the responsibility of the authors and do not represent the official views of these institutions. Publisher Copyright: {\textcopyright} 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.",

year = "2021",

month = feb,

doi = "10.1002/alz.12202",

language = "English",

volume = "17",

pages = "295--313",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "John Wiley & Sons Inc.",

number = "2",

}

Parra, MA, Baez, S, Sedeño, L, Gonzalez Campo, C, Santamaría-García, H, Aprahamian, I, Bertolucci, PHF, Bustin, J, Camargos Bicalho, MA, Cano-Gutierrez, C, Caramelli, P, Chaves, MLF, Cogram, P, Beber, BC, Court, FA, de Souza, LC, Custodio, N, Damian, A, de la Cruz, M, Diehl Rodriguez, R, Brucki, SMD, Fajersztajn, L, Farías, GA, De Felice, FG, Ferrari, R, de Oliveira, FF, Ferreira, ST, Ferretti, C, Figueredo Balthazar, ML, Ferreira Frota, NA, Fuentes, P, García, AM, Garcia, PJ, de Gobbi Porto, FH, Duque Peñailillo, L, Engler, HW, Maier, I, Mata, IF, Gonzalez-Billault, C, Lopez, OL, Morelli, L, Nitrini, R, Quiroz, YT, Guerrero Barragan, A, Huepe, D, Pio, FJ, Suemoto, CK, Kochhann, R, Kochen, S, Kumfor, F, Lanata, S, Miller, B, Mansur, LL, Hosogi, ML, Lillo, P, Llibre Guerra, J, Lira, D, Lopera, F, Comas, A, Avila-Funes, JA, Sosa, AL, Ramos, C, Resende, EDPF, Snyder, HM, Tarnanas, I, Yokoyama, J, Llibre, J, Cardona, JF, Possin, K, Kosik, KS, Montesinos, R, Moguilner, S, Solis, PCL, Ferretti-Rebustini, REDL, Ramirez, JM, Matallana, D, Mbakile-Mahlanza, L, Marques Ton, AM, Tavares, RM, Miotto, EC, Muniz-Terrera, G, Muñoz-Nevárez, LA, Orozco, D, Okada de Oliveira, M, Piguet, O, Pintado Caipa, M, Piña Escudero, SD, Schilling, LP, Rodrigues Palmeira, AL, Yassuda, MS, Santacruz-Escudero, JM, Serafim, RB, Smid, J, Slachevsky, A, Serrano, C, Soto-Añari, M, Takada, LT, Grinberg, LT, Teixeira, AL, Barbosa, MT, Trépel, D & Ibanez, A 2021, 'Dementia in Latin America: Paving the way toward a regional action plan', Alzheimer's and Dementia, vol. 17, no. 2, pp. 295-313. https://doi.org/10.1002/alz.12202

TY - JOUR

T1 - Dementia in Latin America

T2 - Paving the way toward a regional action plan

AU - Parra, Mario Alfredo

AU - Baez, Sandra

AU - Sedeño, Lucas

AU - Gonzalez Campo, Cecilia

AU - Santamaría-García, Hernando

AU - Aprahamian, Ivan

AU - Bertolucci, Paulo H.F.

AU - Bustin, Julian

AU - Camargos Bicalho, Maria Aparecida

AU - Cano-Gutierrez, Carlos

AU - Caramelli, Paulo

AU - Chaves, Marcia L.F.

AU - Cogram, Patricia

AU - Beber, Bárbara Costa

AU - Court, Felipe A.

AU - de Souza, Leonardo Cruz

AU - Custodio, Nilton

AU - Damian, Andres

AU - de la Cruz, Myriam

AU - Diehl Rodriguez, Roberta

AU - Brucki, Sonia Maria Dozzi

AU - Fajersztajn, Lais

AU - Farías, Gonzalo A.

AU - De Felice, Fernanda G.

AU - Ferrari, Raffaele

AU - de Oliveira, Fabricio Ferreira

AU - Ferreira, Sergio T.

AU - Ferretti, Ceres

AU - Figueredo Balthazar, Marcio Luiz

AU - Ferreira Frota, Norberto Anizio

AU - Fuentes, Patricio

AU - García, Adolfo M.

AU - Garcia, Patricia J.

AU - de Gobbi Porto, Fábio Henrique

AU - Duque Peñailillo, Lissette

AU - Engler, Henry Willy

AU - Maier, Irene

AU - Mata, Ignacio F.

AU - Gonzalez-Billault, Christian

AU - Lopez, Oscar L.

AU - Morelli, Laura

AU - Nitrini, Ricardo

AU - Quiroz, Yakeel T.

AU - Guerrero Barragan, Alejandra

AU - Huepe, David

AU - Pio, Fabricio Joao

AU - Suemoto, Claudia Kimie

AU - Kochhann, Renata

AU - Kochen, Silvia

AU - Kumfor, Fiona

AU - Lanata, Serggio

AU - Miller, Bruce

AU - Mansur, Leticia Lessa

AU - Hosogi, Mirna Lie

AU - Lillo, Patricia

AU - Llibre Guerra, Jorge

AU - Lira, David

AU - Lopera, Francisco

AU - Comas, Adelina

AU - Avila-Funes, José Alberto

AU - Sosa, Ana Luisa

AU - Ramos, Claudia

AU - Resende, Elisa de Paula França

AU - Snyder, Heather M.

AU - Tarnanas, Ioannis

AU - Yokoyama, Jenifer

AU - Llibre, Juan

AU - Cardona, Juan Felipe

AU - Possin, Kate

AU - Kosik, Kenneth S.

AU - Montesinos, Rosa

AU - Moguilner, Sebastian

AU - Solis, Patricia Cristina Lourdes

AU - Ferretti-Rebustini, Renata Eloah de Lucena

AU - Ramirez, Jeronimo Martin

AU - Matallana, Diana

AU - Mbakile-Mahlanza, Lingani

AU - Marques Ton, Alyne Mendonça

AU - Tavares, Ronnielly Melo

AU - Miotto, Eliane C.

AU - Muniz-Terrera, Graciela

AU - Muñoz-Nevárez, Luis Arnoldo

AU - Orozco, David

AU - Okada de Oliveira, Maira

AU - Piguet, Olivier

AU - Pintado Caipa, Maritza

AU - Piña Escudero, Stefanie Danielle

AU - Schilling, Lucas Porcello

AU - Rodrigues Palmeira, André Luiz

AU - Yassuda, Mônica Sanches

AU - Santacruz-Escudero, Jose Manuel

AU - Serafim, Rodrigo Bernardo

AU - Smid, Jerusa

AU - Slachevsky, Andrea

AU - Serrano, Cecilia

AU - Soto-Añari, Marcio

AU - Takada, Leonel Tadao

AU - Grinberg, Lea Tenenholz

AU - Teixeira, Antonio Lucio

AU - Barbosa, Maira Tonidandel

AU - Trépel, Dominic

AU - Ibanez, Agustin

N1 - Funding Information: The Expert Meeting was supported by Alzheimer's Society UK grants awarded to MP in collaboration with AI (AS‐R42303, AS‐SF‐14‐008). AS is supported by CONICYT / FONDAP /15150012; Conicyt/ Fondecyt Regular/ 1140423 and Basal Funds for Centers of Excellence, Project FB 0003 from the Associative Research Program of CONICYT. FL is supported by a grant API COLOMBIA funded by GENENTECH and Banner Institute. FK is supported by a National Health and Medical Research Council of Australia (NHMRC)‐Australian Research Council Dementia Research Development Fellowship (APP1097026). OP is supported by an NHMRC Senior Research Fellowship (APP1103258). FFDO is supported by FAPESP ‐ The State of São Paulo Research Foundation (grant #2015/10109‐5). The support from Alzheimer´s Scotland Dementia Research and the Centre for Cognitive Ageing and Cognitive Epidemiology part of the cross council Lifelong Health and Wellbeing Initiative (MR/K026992/1) both from the University of Edinburgh is also acknowledged. FS is supported by Geroscience Center for Brain Health and Metabolism (FONDAP‐15150012) and Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT, No. 1150766). RAV is supported by CONICYT AFB 170008 and by Faculty of Sciences, University of Chile, PAIFAC grant. PC is supported by CNPq, Brazil (bolsa de produtividade em pesquisa). PL is supported by FONDAP Program Grant 15150012 & by Conicyt/Fondecyt Regular/ 1160940. STF is supported by National Institute for Translational Neuroscience (Brazil, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq/Brazil) and Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ/Brazil). BCB is supported by Alzheimer's Association and Global Brain Health Institute (GBHI_ALZ‐18‐542347). LTG is supported by NIH K24AG053435. MLFC is supported by CNPq (bolsa de produtividade em pesquisa). RDR is supported by FAPESP (2016/24326‐0) and the Alzheimer´s Association (AARF‐18‐566005). LD is partially supported by Neuromedicenter. RF is supported by Alzheimer's Society (grant # 284). LCS is supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq/Brazil). MSY is supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq/Brazil) and São Paulo Research Foundation (FAPESP/BRAZIL). MACB is supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq/Brazil) and Minas Gerais Research Foundation (FAPEMIG/BRAZIL). IA receives National public grant level 2 from the National Council for Scientific and Technological Development (Ministry of Science, Technology, Innovation and Communications, Brazil). HMS is a full‐time employee of the Alzheimer's Association. AI is partially supported by grants from CONICET, FONCyT‐PICT 2017‐1818, FONCyT‐PICT 2017‐1820, FONDAP 15150012, the Interamerican Development Bank (IDB), Alzheimer's Association GBHI ALZ UK‐20‐639295, and the MULTI‐PARTNER CONSORTIUM TO EXPAND DEMENTIA RESEARCH IN LATIN AMERICA [ReDLat, supported by National Institutes of Health, National Institute on Aging (R01 AG057234), Alzheimer's Association (SG‐20‐725707), Tau Consortium, and Global Brain Health Institute)]. The contents of this publication are solely the responsibility of the authors and do not represent the official views of these Institutions. The other authors declare no conflict of interests. Funding Information: The authors thank Laura Bleiler from the Alzheimer's Association (AA) for proofreading the article. The authors also thank the Inter‐American Development Bank (IDB) and the the MULTI‐PARTNER CONSORTIUM TO EXPAND DEMENTIA RESEARCH IN LATIN AMERICA [ReDLat, supported by National Institutes of Health, National Institutes of Aging (R01 AG057234), Alzheimer's Association (SG‐20‐725707), Tau Consortium, and Global Brain Health Institute] and the grant Alzheimer's Association GBHI ALZ UK‐20‐639295. The contents of this publication are solely the responsibility of the authors and do not represent the official views of these institutions. Publisher Copyright: © 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.

PY - 2021/2

Y1 - 2021/2

N2 - Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.

AB - Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.

KW - Latin America

KW - biomarkers

KW - clinical trials

KW - dementia

KW - epidemiology

KW - evidence-based recommendations

KW - genetics

KW - knowledge to action framework

KW - networking and translational research

KW - nonpharmacological interventions

UR - http://www.scopus.com/inward/record.url?scp=85095422362&partnerID=8YFLogxK

U2 - 10.1002/alz.12202

DO - 10.1002/alz.12202

M3 - Article

C2 - 33634602

AN - SCOPUS:85095422362

SN - 1552-5260

VL - 17

SP - 295

EP - 313

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 2

ER -

Dementia in Latin America: Paving the way toward a regional action plan

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