TY - JOUR
T1 - Clinical recognition of frontotemporal dementia with right temporal predominance
T2 - a consensus statement from the International Working Group
AU - International rtvFTD working group
AU - Ulugut, Hulya
AU - Younes, Kyan
AU - Montembeault, Maxime
AU - Bertoux, Maxime
AU - Irish, Muireann
AU - Kumfor, Fiona
AU - Fumagalli, Giorgio G.
AU - Samanci, Bedia
AU - Illán-Gala, Ignacio
AU - Thompson, Jennifer C.
AU - Santillo, Alexander F.
AU - Englund, Elisabet
AU - Landqvist Waldö, Maria
AU - Riedl, Lina
AU - Van den Stock, Jan
AU - Vandenbulcke, Mathieu
AU - Vandenberghe, Rik
AU - Laforce, Robert
AU - Ducharme, Simon
AU - Pressman, Peter S.
AU - Caramelli, Paulo
AU - Cruz de Souza, Leonardo
AU - Takada, Leonel T.
AU - Gurvit, Hakan
AU - Diehl-Schmid, Janine
AU - Galimberti, Daniela
AU - Pasquier, Florence
AU - Weintraub, Sandra
AU - Miller, Bruce L.
AU - Sturm, Virginia E.
AU - Whitwell, Jennifer L.
AU - Boeve, Bradley
AU - Rohrer, Jonathan D.
AU - Piguet, Olivier
AU - Gorno-Tempini, Maria Luisa
AU - Josephs, Keith A.
AU - Snowden, Julie
AU - Rowe, James B.
AU - Warren, Jason D.
AU - Rankin, Katherine P.
AU - Pijnenburg, Yolande A.L.
AU - Pijnenburg, Yolande
AU - Huey, Edward D.
AU - Krudop, Welmoed
AU - Miyagawa, Toji
AU - Lebouvier, Thibaud
AU - Lee, Sun Min
AU - Moon, So Young
AU - Thompson, Sian
AU - Ibanez, Agustin
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2025/12
Y1 - 2025/12
N2 - Accurate diagnosis of frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance remains challenging due to lack of clinical characterization, and standardized terminology. The recent research of the International Working Group (IWG) identified common symptoms but also unveiled broad terminologies lacking precision and operationalization, with risk of misdiagnoses, inappropriate referrals and poor clinical management. Based on the published evidence (91267 articles screened) and expert opinion (105 FTD specialists across 52 centers) by using the nominal group technique, the IWG delineates three primary domains of impairment causing behavioral, memory and language problems: (i) multimodal knowledge of non-verbal information including people, living beings, landmarks, flavors/odors, sounds, bodily sensations, emotions and social cues; (ii) socioemotional behavior encompassing emotion expression, social response and motivation; and (iii) prioritization for focus on specific interests, hedonic valuation and personal preferences. This study establishes a consensus on clinical profile, phenotypic nomenclature, and future directions to enhance diagnostic precision and therapeutic interventions.
AB - Accurate diagnosis of frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance remains challenging due to lack of clinical characterization, and standardized terminology. The recent research of the International Working Group (IWG) identified common symptoms but also unveiled broad terminologies lacking precision and operationalization, with risk of misdiagnoses, inappropriate referrals and poor clinical management. Based on the published evidence (91267 articles screened) and expert opinion (105 FTD specialists across 52 centers) by using the nominal group technique, the IWG delineates three primary domains of impairment causing behavioral, memory and language problems: (i) multimodal knowledge of non-verbal information including people, living beings, landmarks, flavors/odors, sounds, bodily sensations, emotions and social cues; (ii) socioemotional behavior encompassing emotion expression, social response and motivation; and (iii) prioritization for focus on specific interests, hedonic valuation and personal preferences. This study establishes a consensus on clinical profile, phenotypic nomenclature, and future directions to enhance diagnostic precision and therapeutic interventions.
UR - https://www.scopus.com/pages/publications/105025118071
U2 - 10.1038/s43856-025-01252-4
DO - 10.1038/s43856-025-01252-4
M3 - Review article
AN - SCOPUS:105025118071
SN - 2730-664X
VL - 5
JO - Communications Medicine
JF - Communications Medicine
IS - 1
M1 - 523
ER -
