Circulating metabolites are associated with brain atrophy and white matter hyperintensities

Francisca A. de Leeuw; Hata Karamujić-Čomić; Betty M. Tijms; Carel F.W. Peeters; Maartje I. Kester; Philip Scheltens; Shahzad Ahmad; Dina Vojinovic; Hieab H.H. Adams; Thomas Hankemeier; Daniel Bos; Aad van der Lugt; Meike W. Vernooij; M. Arfan Ikram; Najaf Amin; Frederik Barkhof; Charlotte E. Teunissen; Cornelia M. van Duijn; Wiesje M. van der Flier

doi:10.1002/alz.12180

Circulating metabolites are associated with brain atrophy and white matter hyperintensities

Francisca A. de Leeuw, Hata Karamujić-Čomić, Betty M. Tijms, Carel F.W. Peeters, Maartje I. Kester, Philip Scheltens, Shahzad Ahmad, Dina Vojinovic, Hieab H.H. Adams, Thomas Hankemeier, Daniel Bos, Aad van der Lugt, Meike W. Vernooij, M. Arfan Ikram, Najaf Amin, Frederik Barkhof, Charlotte E. Teunissen, Cornelia M. van Duijn, Wiesje M. van der Flier

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Introduction: Our aim was to study whether systemic metabolites are associated with magnetic resonance imaging (MRI) measures of brain and hippocampal atrophy and white matter hyperintensities (WMH). Methods: We studied associations of 143 plasma-based metabolites with MRI measures of brain and hippocampal atrophy and WMH in three independent cohorts (n = 3962). We meta-analyzed the results of linear regression analyses to determine the association of metabolites with MRI measures. Results: Higher glucose levels and lower levels of three small high density lipoprotein (HDL) particles were associated with brain atrophy. Higher glucose levels were associated with WMH. Discussion: Glucose levels were associated with brain atrophy and WMH, and small HDL particle levels were associated with brain atrophy. Circulating metabolites may aid in developing future intervention trials.

Original language	English
Pages (from-to)	205-214
Number of pages	10
Journal	Alzheimer's and Dementia
Volume	17
Issue number	2
DOIs	https://doi.org/10.1002/alz.12180
State	Published - Feb 2021
Externally published	Yes

Keywords

Alzheimer's disease
cholesterol
glucose
lipids
magnetic resonance imaging (MRI)
metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/alz.12180

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de Leeuw, F. A., Karamujić-Čomić, H., Tijms, B. M., Peeters, C. F. W., Kester, M. I., Scheltens, P., Ahmad, S., Vojinovic, D., Adams, H. H. H., Hankemeier, T., Bos, D., van der Lugt, A., Vernooij, M. W., Ikram, M. A., Amin, N., Barkhof, F., Teunissen, C. E., van Duijn, C. M., & van der Flier, W. M. (2021). Circulating metabolites are associated with brain atrophy and white matter hyperintensities. Alzheimer's and Dementia, 17(2), 205-214. https://doi.org/10.1002/alz.12180

@article{e1286ac09a294385b92751effdbd97be,

title = "Circulating metabolites are associated with brain atrophy and white matter hyperintensities",

abstract = "Introduction: Our aim was to study whether systemic metabolites are associated with magnetic resonance imaging (MRI) measures of brain and hippocampal atrophy and white matter hyperintensities (WMH). Methods: We studied associations of 143 plasma-based metabolites with MRI measures of brain and hippocampal atrophy and WMH in three independent cohorts (n = 3962). We meta-analyzed the results of linear regression analyses to determine the association of metabolites with MRI measures. Results: Higher glucose levels and lower levels of three small high density lipoprotein (HDL) particles were associated with brain atrophy. Higher glucose levels were associated with WMH. Discussion: Glucose levels were associated with brain atrophy and WMH, and small HDL particle levels were associated with brain atrophy. Circulating metabolites may aid in developing future intervention trials.",

keywords = "Alzheimer's disease, cholesterol, glucose, lipids, magnetic resonance imaging (MRI), metabolism",

author = "{de Leeuw}, {Francisca A.} and Hata Karamuji{\'c}-{\v C}omi{\'c} and Tijms, {Betty M.} and Peeters, {Carel F.W.} and Kester, {Maartje I.} and Philip Scheltens and Shahzad Ahmad and Dina Vojinovic and Adams, {Hieab H.H.} and Thomas Hankemeier and Daniel Bos and {van der Lugt}, Aad and Vernooij, {Meike W.} and Ikram, {M. Arfan} and Najaf Amin and Frederik Barkhof and Teunissen, {Charlotte E.} and {van Duijn}, {Cornelia M.} and {van der Flier}, {Wiesje M.}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.",

year = "2021",

month = feb,

doi = "10.1002/alz.12180",

language = "English",

volume = "17",

pages = "205--214",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "John Wiley & Sons Inc.",

number = "2",

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de Leeuw, FA, Karamujić-Čomić, H, Tijms, BM, Peeters, CFW, Kester, MI, Scheltens, P, Ahmad, S, Vojinovic, D, Adams, HHH, Hankemeier, T, Bos, D, van der Lugt, A, Vernooij, MW, Ikram, MA, Amin, N, Barkhof, F, Teunissen, CE, van Duijn, CM & van der Flier, WM 2021, 'Circulating metabolites are associated with brain atrophy and white matter hyperintensities', Alzheimer's and Dementia, vol. 17, no. 2, pp. 205-214. https://doi.org/10.1002/alz.12180

TY - JOUR

T1 - Circulating metabolites are associated with brain atrophy and white matter hyperintensities

AU - de Leeuw, Francisca A.

AU - Karamujić-Čomić, Hata

AU - Tijms, Betty M.

AU - Peeters, Carel F.W.

AU - Kester, Maartje I.

AU - Scheltens, Philip

AU - Ahmad, Shahzad

AU - Vojinovic, Dina

AU - Adams, Hieab H.H.

AU - Hankemeier, Thomas

AU - Bos, Daniel

AU - van der Lugt, Aad

AU - Vernooij, Meike W.

AU - Ikram, M. Arfan

AU - Amin, Najaf

AU - Barkhof, Frederik

AU - Teunissen, Charlotte E.

AU - van Duijn, Cornelia M.

AU - van der Flier, Wiesje M.

PY - 2021/2

Y1 - 2021/2

N2 - Introduction: Our aim was to study whether systemic metabolites are associated with magnetic resonance imaging (MRI) measures of brain and hippocampal atrophy and white matter hyperintensities (WMH). Methods: We studied associations of 143 plasma-based metabolites with MRI measures of brain and hippocampal atrophy and WMH in three independent cohorts (n = 3962). We meta-analyzed the results of linear regression analyses to determine the association of metabolites with MRI measures. Results: Higher glucose levels and lower levels of three small high density lipoprotein (HDL) particles were associated with brain atrophy. Higher glucose levels were associated with WMH. Discussion: Glucose levels were associated with brain atrophy and WMH, and small HDL particle levels were associated with brain atrophy. Circulating metabolites may aid in developing future intervention trials.

AB - Introduction: Our aim was to study whether systemic metabolites are associated with magnetic resonance imaging (MRI) measures of brain and hippocampal atrophy and white matter hyperintensities (WMH). Methods: We studied associations of 143 plasma-based metabolites with MRI measures of brain and hippocampal atrophy and WMH in three independent cohorts (n = 3962). We meta-analyzed the results of linear regression analyses to determine the association of metabolites with MRI measures. Results: Higher glucose levels and lower levels of three small high density lipoprotein (HDL) particles were associated with brain atrophy. Higher glucose levels were associated with WMH. Discussion: Glucose levels were associated with brain atrophy and WMH, and small HDL particle levels were associated with brain atrophy. Circulating metabolites may aid in developing future intervention trials.

KW - Alzheimer's disease

KW - cholesterol

KW - glucose

KW - lipids

KW - magnetic resonance imaging (MRI)

KW - metabolism

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U2 - 10.1002/alz.12180

DO - 10.1002/alz.12180

M3 - Article

C2 - 32886448

AN - SCOPUS:85090236449

SN - 1552-5260

VL - 17

SP - 205

EP - 214

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 2

ER -

Circulating metabolites are associated with brain atrophy and white matter hyperintensities

Abstract

Keywords

UN SDGs

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