Chitosan capped copper oxide/copper nanoparticles encapsulated microbial resistant nanocomposite films

Tippabattini Jayaramudu, Kokkarachedu Varaprasad, Radha D. Pyarasani, K. Koteshwara Reddy, Kanderi Dileep Kumar, A. Akbari-Fakhrabadi, R. V. Mangalaraja, John Amalraj

Research output: Contribution to journalArticlepeer-review

94 Scopus citations


Chitosan (CH) capped inorganic nanomaterials have been considered as significant antibacterial materials in the clinical field. This work shows the synthesis of two new different antibacterial composite films as a result of the incorporation of CH capped copper oxide (CHCuO) and copper (CHCu) nanoparticles (NPs). Here, CHCuO and CHCu NPs were achieved by a facile chemical reduction of Cu2+ ions using sodium hydroxide and ascorbic acid. TEM analysis revealed the morphology as rod-type nanoflakes for CHCuO and a spherical shape for CHCu NPs with ~7 ± 2 nm size. Antimicrobial activity of the developed materials was studied by the inhibition zone method, against both gram-negative and gram-positive bacteria. The antimicrobial activity revealed that the CHCuO NPs and CHCuO-CH film showed a higher inhibition zone than the other nanomaterials. The results suggested that the synthesized materials can be used in wound dressing applications.

Original languageEnglish
Pages (from-to)499-508
Number of pages10
JournalInternational Journal of Biological Macromolecules
StatePublished - 1 May 2019
Externally publishedYes


  • CHCu NPs
  • CHCuO NPs
  • Chitosan


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