TY - JOUR
T1 - Chitosan capped copper oxide/copper nanoparticles encapsulated microbial resistant nanocomposite films
AU - Jayaramudu, Tippabattini
AU - Varaprasad, Kokkarachedu
AU - Pyarasani, Radha D.
AU - Reddy, K. Koteshwara
AU - Kumar, Kanderi Dileep
AU - Akbari-Fakhrabadi, A.
AU - Mangalaraja, R. V.
AU - Amalraj, John
N1 - Publisher Copyright:
© 2019
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Chitosan (CH) capped inorganic nanomaterials have been considered as significant antibacterial materials in the clinical field. This work shows the synthesis of two new different antibacterial composite films as a result of the incorporation of CH capped copper oxide (CHCuO) and copper (CHCu) nanoparticles (NPs). Here, CHCuO and CHCu NPs were achieved by a facile chemical reduction of Cu2+ ions using sodium hydroxide and ascorbic acid. TEM analysis revealed the morphology as rod-type nanoflakes for CHCuO and a spherical shape for CHCu NPs with ~7 ± 2 nm size. Antimicrobial activity of the developed materials was studied by the inhibition zone method, against both gram-negative and gram-positive bacteria. The antimicrobial activity revealed that the CHCuO NPs and CHCuO-CH film showed a higher inhibition zone than the other nanomaterials. The results suggested that the synthesized materials can be used in wound dressing applications.
AB - Chitosan (CH) capped inorganic nanomaterials have been considered as significant antibacterial materials in the clinical field. This work shows the synthesis of two new different antibacterial composite films as a result of the incorporation of CH capped copper oxide (CHCuO) and copper (CHCu) nanoparticles (NPs). Here, CHCuO and CHCu NPs were achieved by a facile chemical reduction of Cu2+ ions using sodium hydroxide and ascorbic acid. TEM analysis revealed the morphology as rod-type nanoflakes for CHCuO and a spherical shape for CHCu NPs with ~7 ± 2 nm size. Antimicrobial activity of the developed materials was studied by the inhibition zone method, against both gram-negative and gram-positive bacteria. The antimicrobial activity revealed that the CHCuO NPs and CHCuO-CH film showed a higher inhibition zone than the other nanomaterials. The results suggested that the synthesized materials can be used in wound dressing applications.
KW - CHCu NPs
KW - CHCuO NPs
KW - Chitosan
UR - http://www.scopus.com/inward/record.url?scp=85060873021&partnerID=8YFLogxK
U2 - 10.1016/j.ijbiomac.2019.01.145
DO - 10.1016/j.ijbiomac.2019.01.145
M3 - Article
C2 - 30699337
AN - SCOPUS:85060873021
SN - 0141-8130
VL - 128
SP - 499
EP - 508
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
ER -