TY - JOUR
T1 - Antibacterial activity and fluorescence properties of 4,7-dichloro-2-quinolinemethylacrylate
AU - Valle, Hernán
AU - Viswanathan Mangalaraja, Ramalinga
AU - Aguilar, Luis
AU - Carrasco, Carlos
AU - Padilla, Natalia
AU - Dahrouch, Mohamed
AU - Rivas, Bernabé
AU - Urrutia, Homero
N1 - Publisher Copyright:
© 2020 Sociedad Chilena de Quimica. All rights reserved.
PY - 2020/6
Y1 - 2020/6
N2 - Currently, some quinoline-based anticancer drugs are successful repurposed for treatment of bacterial infections. This study assessed the antibacterial activity of the new anticancer compound 4,7-dichloro-2-quinolinemethylacrylate (AQM) against bacteria of both clinical and agricultural interest, and also determined the influence of some metal cations (Fe3+, Mn2+, Zn2+, Na+, Mg2+, Co2+ and Ni2+) on the AQM photophysics. The synthesis of AQM was carried out by the reported method. The antibacterial activity of AQM on Pectobacterium carotovorum subsp. carotovorum (Pcc), Ralstonia solanacearum, Klebsiella pneuminiae, Pseudomonas syringae, Staphylococcus aureus y Bacillus sp., was evaluated using the spectrophotometric method of broth microdilution. At 125 ppm, AQM produced growth inhibition of 51.7% in Pcc, and a bacteriostatic effect in S. aureus and Bacillus sp., but no effect was seen against the other bacteria. In addition, fluorescence quenching of AQM solution induced only by Fe3+ ion, and not by the other metal cations, was confirmed. These results postulate that AQM could be a molecule with potential application in antibacterial therapy or in the fluorometric detection of Fe3+ ions.
AB - Currently, some quinoline-based anticancer drugs are successful repurposed for treatment of bacterial infections. This study assessed the antibacterial activity of the new anticancer compound 4,7-dichloro-2-quinolinemethylacrylate (AQM) against bacteria of both clinical and agricultural interest, and also determined the influence of some metal cations (Fe3+, Mn2+, Zn2+, Na+, Mg2+, Co2+ and Ni2+) on the AQM photophysics. The synthesis of AQM was carried out by the reported method. The antibacterial activity of AQM on Pectobacterium carotovorum subsp. carotovorum (Pcc), Ralstonia solanacearum, Klebsiella pneuminiae, Pseudomonas syringae, Staphylococcus aureus y Bacillus sp., was evaluated using the spectrophotometric method of broth microdilution. At 125 ppm, AQM produced growth inhibition of 51.7% in Pcc, and a bacteriostatic effect in S. aureus and Bacillus sp., but no effect was seen against the other bacteria. In addition, fluorescence quenching of AQM solution induced only by Fe3+ ion, and not by the other metal cations, was confirmed. These results postulate that AQM could be a molecule with potential application in antibacterial therapy or in the fluorometric detection of Fe3+ ions.
KW - Antibacterial activity
KW - Broth microdilution
KW - Fluorescence quenching
KW - Quinoline
UR - http://www.scopus.com/inward/record.url?scp=85090602554&partnerID=8YFLogxK
U2 - 10.4067/S0717-97072020000204784
DO - 10.4067/S0717-97072020000204784
M3 - Article
AN - SCOPUS:85090602554
SN - 0717-9324
VL - 65
SP - 4784
EP - 4789
JO - Journal of the Chilean Chemical Society
JF - Journal of the Chilean Chemical Society
IS - 2
ER -