Alzheimer's Disease or Behavioral Variant Frontotemporal Dementia? Review of Key Points Toward an Accurate Clinical and Neuropsychological Diagnosis

Gada Musa, Andrea Slachevsky, Carlos Muñoz-Neira, Carolina Méndez-Orellana, Roque Villagra, Christian González-Billault, Agustín Ibáñez, Michael Hornberger, Patricia Lillo

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Alzheimer's disease (AD) and frontotemporal dementia (FTD) are the most common neurodegenerative early-onset dementias. Despite the fact that both conditions have a very distinctive clinical pattern, they present with an overlap in their cognitive and behavioral features that may lead to misdiagnosis or delay in diagnosis. The current review intends to summarize briefly the main differences at the clinical, neuropsychological, and behavioral levels, in an attempt to suggest which aspects would facilitate an adequate diagnosis in a clinical setting, especially in Latin American and low- and middle-income countries, where the resources needed for a differential diagnosis (such as MRI or biomarkers) are not always available. A timely diagnosis of AD and FTD have significant implications for the medical management and quality of life of patients and careers.

Original languageEnglish
Pages (from-to)833-848
Number of pages16
JournalJournal of Alzheimer's Disease
Volume73
Issue number3
DOIs
StatePublished - 2020
Externally publishedYes

Keywords

  • Alzheimer’s disease
  • differential diagnosis
  • frontotemporal dementia
  • neuropsychology
  • young onset dementia

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