Altered neural signatures of interoception in multiple sclerosis

Paula C. Salamone, Sol Esteves, Vladimiro J. Sinay, Indira García-Cordero, Sofía Abrevaya, Blas Couto, Federico Adolfi, Miguel Martorell, Agustín Petroni, Adrián Yoris, Kathya Torquati, Florencia Alifano, Agustina Legaz, Fátima P. Cassará, Diana Bruno, Andrew H. Kemp, Eduar Herrera, Adolfo M. García, Agustín Ibáñez, Lucas Sedeño

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Multiple sclerosis (MS) patients present several alterations related to sensing of bodily signals. However, no specific neurocognitive impairment has yet been proposed as a core deficit underlying such symptoms. We aimed to determine whether MS patients present changes in interoception—that is, the monitoring of autonomic bodily information—a process that might be related to various bodily dysfunctions. We performed two studies in 34 relapsing–remitting, early-stage MS patients and 46 controls matched for gender, age, and education. In Study 1, we evaluated the heartbeat-evoked potential (HEP), a cortical signature of interoception, via a 128-channel EEG system during a heartbeat detection task including an exteroceptive and an interoceptive condition. Then, we obtained whole-brain MRI recordings. In Study 2, participants underwent fMRI recordings during two resting-state conditions: mind wandering and interoception. In Study 1, controls exhibited greater HEP modulation during the interoceptive condition than the exteroceptive one, but no systematic differences between conditions emerged in MS patients. Patients presented atrophy in the left insula, the posterior part of the right insula, and the right anterior cingulate cortex, with abnormal associations between neurophysiological and neuroanatomical patterns. In Study 2, controls showed higher functional connectivity and degree for the interoceptive state compared with mind wandering; however, this pattern was absent in patients, who nonetheless presented greater connectivity and degree than controls during mind wandering. MS patients were characterized by atypical multimodal brain signatures of interoception. This finding opens a new agenda to examine the role of inner-signal monitoring in the body symptomatology of MS.

Original languageEnglish
Pages (from-to)4743-4754
Number of pages12
JournalHuman Brain Mapping
Volume39
Issue number12
DOIs
StatePublished - Dec 2018

Keywords

  • body perception
  • functional connectivity
  • heartbeat detection task
  • heartbeat evoked potential
  • interoceptive processing
  • multiple sclerosis

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