Agregados amiloides: Rol en desórdenes de conformación proteica

Translated title of the contribution: Amyloid aggregates: Role in protein misfolding disorders

Claudia Duran-Aniotz, Inés Moreno-Gonzalez, Rodrigo Morales

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Misfolding and aggregation of proteins are the main features of a group of diseases termed Protein Misfolding Disorders (PMDs). PMDs include Alzheimer's disease and Transmissible Spongiform Encephalopathies, among many others. The deposition of protein aggregates is the main responsible for tissue damage and the consequent clinical signs generated in such disorders. In this review, we will focus in the role of protein aggregates in these diseases and in the putative mechanisms by which they exert their toxicity.

Translated title of the contributionAmyloid aggregates: Role in protein misfolding disorders
Original languageSpanish
Pages (from-to)495-505
Number of pages11
JournalRevista Medica de Chile
Volume141
Issue number4
DOIs
StatePublished - Apr 2013

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