A predictive coding framework of allostatic–interoceptive overload in frontotemporal dementia

Joaquin A. Migeot, Claudia A. Duran-Aniotz, Camilo M. Signorelli, Olivier Piguet, Agustín Ibáñez

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Recent allostatic–interoceptive explanations using predictive coding models propose that efficient regulation of the body's internal milieu is necessary to correctly anticipate environmental needs. We review this framework applied to understanding behavioral variant frontotemporal dementia (bvFTD) considering both allostatic overload and interoceptive deficits. First, we show how this framework could explain divergent deficits in bvFTD (cognitive impairments, behavioral maladjustment, brain atrophy, fronto-insular-temporal network atypicality, aberrant interoceptive electrophysiological activity, and autonomic disbalance). We develop a set of theory-driven predictions based on levels of allostatic interoception associated with bvFTD phenomenology and related physiopathological mechanisms. This approach may help further understand the disparate behavioral and physiopathological dysregulations of bvFTD, suggesting targeted interventions and strengthening clinical models of neurological and psychiatric disorders.

Original languageEnglish
Pages (from-to)838-853
Number of pages16
JournalTrends in Neurosciences
Issue number11
StatePublished - Nov 2022
Externally publishedYes


  • allostatic interoception
  • allostatic overload
  • frontotemporal dementia
  • interoception
  • predictive coding


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