TY - JOUR
T1 - A predictive coding framework of allostatic–interoceptive overload in frontotemporal dementia
AU - Migeot, Joaquin A.
AU - Duran-Aniotz, Claudia A.
AU - Signorelli, Camilo M.
AU - Piguet, Olivier
AU - Ibáñez, Agustín
N1 - Publisher Copyright:
© 2022 The Author(s)
PY - 2022/11
Y1 - 2022/11
N2 - Recent allostatic–interoceptive explanations using predictive coding models propose that efficient regulation of the body's internal milieu is necessary to correctly anticipate environmental needs. We review this framework applied to understanding behavioral variant frontotemporal dementia (bvFTD) considering both allostatic overload and interoceptive deficits. First, we show how this framework could explain divergent deficits in bvFTD (cognitive impairments, behavioral maladjustment, brain atrophy, fronto-insular-temporal network atypicality, aberrant interoceptive electrophysiological activity, and autonomic disbalance). We develop a set of theory-driven predictions based on levels of allostatic interoception associated with bvFTD phenomenology and related physiopathological mechanisms. This approach may help further understand the disparate behavioral and physiopathological dysregulations of bvFTD, suggesting targeted interventions and strengthening clinical models of neurological and psychiatric disorders.
AB - Recent allostatic–interoceptive explanations using predictive coding models propose that efficient regulation of the body's internal milieu is necessary to correctly anticipate environmental needs. We review this framework applied to understanding behavioral variant frontotemporal dementia (bvFTD) considering both allostatic overload and interoceptive deficits. First, we show how this framework could explain divergent deficits in bvFTD (cognitive impairments, behavioral maladjustment, brain atrophy, fronto-insular-temporal network atypicality, aberrant interoceptive electrophysiological activity, and autonomic disbalance). We develop a set of theory-driven predictions based on levels of allostatic interoception associated with bvFTD phenomenology and related physiopathological mechanisms. This approach may help further understand the disparate behavioral and physiopathological dysregulations of bvFTD, suggesting targeted interventions and strengthening clinical models of neurological and psychiatric disorders.
KW - allostatic interoception
KW - allostatic overload
KW - frontotemporal dementia
KW - interoception
KW - predictive coding
UR - http://www.scopus.com/inward/record.url?scp=85137026288&partnerID=8YFLogxK
U2 - 10.1016/j.tins.2022.08.005
DO - 10.1016/j.tins.2022.08.005
M3 - Review article
AN - SCOPUS:85137026288
SN - 0166-2236
VL - 45
SP - 838
EP - 853
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 11
ER -